can a touch range spell with multiple targets (upcast enhance ability, twinned cure wounds, etc) be used on one target the caster touches and one the familiar touches, or does it need to be both familiar or both caster? Either the familiar delivers the spell or you do.

— Jeremy Crawford (@JeremyECrawford) April 3, 2018

@JeremyECrawford follow up question.
Since the familiar uses it’s reaction to deliver the spell, it can’t use the ready action to wait for its wizard to cast a spell. Does this mean a wizard must use ready to wait until the familiars turn to deliver a spell (using his reaction)

— James Hardie (@TweetlessJames) April 3, 2018

The find familiar spell gives your familiar the ability to deliver your touch spell using the familiar's reaction. The familiar doesn't need to ready that reaction. It can just do it. Here's how it works: You cast the touch spell. Your familiar uses its reaction. The end. #DnD https://t.co/18gfXKMrkx

— Jeremy Crawford (@JeremyECrawford) April 3, 2018