If a PC wanted to represent a disabled character how would one go about that in terms of how it would change normal gameplay?

I’m curious, if a PC wanted to represent a disabled character, such as if they were in a wheelchair, how would one go about that in terms of how it would change normal gameplay?I might just treat it as a flavor thing, rather than worry too much about mechanics. By rules, someone in a wheelchair doesn’t suffer any penalties or bonuses. Sitting isn’t something reflected in mechanics

— Mike Mearls (@mikemearls) December 3, 2017